This is fascinating. The claim is an enzyme has a domain unrelated to its main binding site that (accidentally?) regulates transcription of genes implicated in Alzheimer’s. Binding that domain with a small molecule can inhibit its role in advancing the disease. scitechdaily.com/scientists-d...
Scientists Discover Hidden Cause of Alzheimer’s Hiding in Plain Sight
Link Preview: Scientists Discover Hidden Cause of Alzheimer’s Hiding in Plain Sight: Researchers found the PHGDH gene directly causes Alzheimer’s and discovered a drug-like molecule, NCT-503, that may help treat the disease early by targeting the gene’s hidden function. A recent study...